M-LEEAD Intranet: Subsidy Request Applications

Subsidy Request Applications

10 people have submitted the Subsidy Request Application.

MiCores Application for Rita Loch-Caruso (2017-2018): ID: 29 Timestamp: 2019-01-20 17:07:10 Project_ID: x9l7of PI_Uniqname: rlc PI_Name_First: Rita PI_Name_Last: Loch-Caruso PI_Email: rlc@umich.edu PI_Phone: 734-936-1256 PI_Affiliation: Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff Program in the Environment - Faculty and Staff School for Environ and Sustain - Faculty and Staff PI_Title: Professor of Toxicology, Department of Environmental Health Sciences, School of Public Health and Professor of Program in the Environment, School for Environment and Sustainability PI_PostalAddress: Environmental Hlth Sci M6108 SPH2, 1415 Washington Hts. Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: $1400 Project_Description: Diethylhexyl phthalate (DEHP) is an environmental toxicant linked to preterm birth and preeclampsia. However, the specific mechanisms of by which these compounds contribute to these adverse birth outcomes is still unclear. The proposed work will use metabolomics to measure changes in hormones and eicosanoids in the blood of pregnant rats in order to gain insight into circulating markers of DEHP exposure and the mechanisms by which exposure might lead to adverse pregnancy outcomes. Our lab has generated serum samples from pregnant rats treated with DEHP at multiple doses (0, 1, 10 or 100mg/kg/day from gestational days 12-16, IACUC #PRO00006721). We are requesting a subsidy in order to partially cover the costs of this analysis using the Michigan Regional Comprehensive Metabolomics Resource Core. This work addresses the mission of M-LEEAD by providing new information on the contribution of an environmental contaminant to the etiology of adverse pregnancy outcomes. Project_Cores: Metabolomics Project_Assay: Targeted metabolomics analysis for hormones and prostanoids in blood serum samples from pregnant rats. Contact_Name_Display: Faith Bjork Contact_Email: fbjork@umich.edu Contact_Phone: 936-1826 Project_Cost_Billing_Date: Feb 28 2019 Acknowledgement: Yes
MiCores Application for Dana Dolinoy (2017-2018): ID: 28 Timestamp: 2019-01-18 14:40:44 Project_ID: tdb06h PI_Uniqname: ddolinoy PI_Name_First: Dana PI_Name_Last: Dolinoy PI_Email: ddolinoy@umich.edu PI_Phone: 734-647-3155 PI_Affiliation: Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff Nutritional Sciences - Faculty and Staff PI_Title: NSF International Department Chair of Environmental Health Sciences, Chair, Department of Environmental Health Sciences, Professor of Environmental Health Sciences and Professor of Nutritional Sciences, School of Public Health. PI_PostalAddress: Environmental Health Sciences 6667 SPH I/1415 Washington Heights Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: 1400 Project_Description: Early life exposure to environmental toxicants can have an adverse effect on later life health in both humans and animals. Epigenetic mechanisms, such as DNA methylation, can be used as potential biomarkers of disease states and environmental exposures. Utilizing an established mouse model of perinatal exposures to human-relevant doses of Lead and DEHP, the goal of the project is to evaluate tissue and cell specific epigenetic alterations associated with these perinatal exposures and later health outcomes. Project_Cores: Epigenomics Project_Assay: Enhanced Reduced Representation Bisulfite Sequencing (ERRBS) will be performed by the University of Michigan Epigenomics Core on DNA samples isolated from multiple different tissues of mice perinatally exposed to either lead, DEHP, or control conditions. Genome-wide methylation profiles will be analyzed for correlation with these toxicant exposures. Contact_Name_Display: Tamara Jones Contact_Email: trmeier@umich.edu Contact_Phone: 734-764-6213 Project_Cost_Billing_Date: March 1, 2019 Acknowledgement: Yes
MiCores Application for John Meeker (2017-2018): ID: 27 Timestamp: 2018-09-19 14:44:00 Project_ID: olgrdj PI_Uniqname: meekerj PI_Name_First: John PI_Name_Last: Meeker PI_Email: meekerj@umich.edu PI_Phone: 734-764-7184 PI_Affiliation: Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff Sch of Public Hlth-Dean's Ofc - Faculty and Staff HITS OCIO Administration - Sponsored Affiliate PI_Title: Professor of Environmental Health Sciences and Senior Associate Dean for Research, School of Public Health PI_PostalAddress: Environmental Hlth Science M6226 SPH II 2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: $1400 Project_Description: Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth. Project_Cores: Metabolomics Project_Assay: Two assays will be performed. Untargeted Metabolomics and Shotgun Lipidomics Contact_Name_Display: Jennifer Fernandez Contact_Email: jafernan@umich.edu Contact_Phone: 734-763-0656 Project_Cost_Billing_Date: Already billed Acknowledgement: Yes
MiCores Application for Jaclyn Goodrich (2017-2018): ID: 26 Timestamp: 2018-09-13 14:40:09 Project_ID: v6kf53 PI_Uniqname: gaydojac PI_Name_First: Jaclyn PI_Name_Middle: Michelle PI_Name_Last: Goodrich PI_Email: gaydojac@umich.edu PI_Phone: 734-647-4564 PI_Affiliation: Environmental Health Sciences, School of Public Health PI_Title: Research Assistant Professor PI_PostalAddress: 1415 Washington Heights Environmental Health Sciences Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: 1400 Project_Description: Environmental exposures may perturb epigenetic programming during key developmental periods including early gestation, thereby setting the stage for adverse birth outcomes and disease development later in life. Discovering the exposures and their potential mechanisms (e.g., epigenetics) underlying this risk is in line with the mission of the M-LEEaD. In this project, we will utilize samples from the Michigan Mother Infant Pairs (MMIP) birth cohort. The overall objectives for the study are to identify toxicants that influence birth outcomes and to examine whether DNA methylation is altered by these exposures, serving as a potential mechanism of toxicity. While exposure assessment and preliminary epigenetic measures are complete, we are now submitting an additional 64 cord blood leukocyte samples for DNA methylation analysis via the MethylationEPIC to increase sample size and power to detect associations between exposures, differentially methylated genes, and birth outcomes. Project_Cores: Epigenomics, OBIC Project_Cores_OBIC: DNA Sequencing Core Project_Assay: DNA methylation analysis will be performed at the DNA Sequencing Core via the Infinium MethlationEPIC BeadChip (Illumina). This array quantifies methylation at >850,000 CpG sites throughout the human genome. DNA isolated from 64 umbilical cord blood leukocyte samples will be bisulfite converted and sent to the DNA Sequencing Core. There, it will be hybridized to the BeadChips and scanned. Raw image data will be returned to the investigators for processing and statistical analysis to address study objectives. Of note, this project involves a collaboration between M-LEEaD members Drs. Padmanabhan and Goodrich as well as Dr. Charles Burant. The analysis will be paid for by an account of Dr. Burantâ??s, but Dr. Goodrich is requesting for the P30 subsidy to be applied to this project that we are jointly working on. Project_Cost_Billing_Date: 10/30/18 Acknowledgement: Yes
MiCores Application for Laurie Svoboda (2017-2018): ID: 25 Timestamp: 2018-08-09 16:33:45 Project_ID: y5ople PI_Uniqname: lmyrant PI_Name_First: Laurie PI_Name_Middle: Kathleen PI_Name_Last: Svoboda PI_Email: lmyrant@umich.edu PI_Phone: 734-764-2032 PI_Affiliation: Alumni Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff HITS OCIO Administration - Sponsored Affiliate PI_Title: Research Assistant Professor, Environmental Health Sciences, School of Public Health PI_PostalAddress: SPH Environmental Health Sciences 1415 Washington Heights Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: $1400 Project_Description: Cardiovascular diseases are a major cause of morbidity and mortality world-wide, and accumulating evidence suggests an important role for early-life toxicant exposures, including lead (Pb), in their etiology. As developmental Pb exposure remains a public health concern in both industrialized and developing nations, a better understanding of how Pb contributes to cardiovascular diseases is urgently needed. Despite known impacts of Pb exposure on heart function, the effects of Pb on the cardiac transcriptome and epigenome have not been investigated. the purpose of this proposal is to test the hypothesis that exposure to Pb in utero and during lactation leads to changes in the transcriptome of the heart, particularly in environmentally labile genes critical for normal cardiac development and physiology. Project_Cores: Bioinformatics, Epigenomics Project_Assay: RNA-seq will be conducted on pulverized heart tissue from mice exposed to Pb or control conditions during gestation and lactation. To assess the contribution of age and sex to the effects of Pb on the cardiac transcriptome, male and female mice will be evaluated at two time points. Tissue cryo pulverization and aliquotting will be conducted by the Epigenomics Core. Estimated cost for this service is approximately $1000 (estimate provided by Dr. Claudia Lalancette). QC analysis, alignment to the mouse reference genome, and differential expression testing, and gene set enrichment analysis will be conducted with the assistance of the M-LEEaD Omics and BioInformatics Core. Project_Cost_Billing_Date: 11/8/18 Acknowledgement: Yes
MiCores Application for Robin Wylie (2017-2018): ID: 24 Timestamp: 2018-08-06 10:45:59 Project_ID: kg3jfe PI_Uniqname: wylie PI_Name_First: Robin PI_Name_Last: Wylie PI_Email: wylie@umich.edu PI_Phone: 734-615-9575 PI_Affiliation: Epidemiology Department - Faculty and Staff School of Public Health - Faculty and Staff PI_Title: Web Designer/Administrative Intermediate PI_PostalAddress: Epidemiology 6638 SPH I Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: 999 Project_Description: Project_Description Project_Cores: Bioinformatics, Epigenomics, Metabolomics, EAC, OBIC, IHSC Project_Cores_EAC: Project_Cores_EAC Project_Cores_OBIC: Project_Cores_OBIC Project_Cores_IHSC: Project_Cores_IHSC Project_Assay: Project_Assay Contact_Name_Display: Contact_Name_Display Contact_Email: example@example.com Contact_Phone: 1234567890 Project_Cost_Billing_Date: Project_Cost_Billing_Date Acknowledgement: Yes
MiCores Application for Robin Wylie (2017-2018): ID: 23 Timestamp: 2018-08-06 10:38:11 Project_ID: lxj8r2 PI_Uniqname: wylie PI_Name_First: Robin PI_Name_Middle: PI_Name_Middle PI_Name_Last: Wylie PI_Email: wylie@umich.edu PI_Phone: 734-615-9575 PI_Affiliation: Epidemiology Department - Faculty and Staff School of Public Health - Faculty and Staff PI_Title: Web Designer/Administrative Intermediate PI_PostalAddress: Epidemiology 6638 SPH I Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: 999 Project_Description: Project_Description Project_Cores: Bioinformatics, Epigenomics, Metabolomics, EAC, OBIC, IHSC Project_Cores_EAC: Project_Cores_EAC Project_Cores_OBIC: Project_Cores_OBIC Project_Cores_IHSC: Project_Cores_IHSC Project_Assay: Project_Assay Contact_Name_Display: Contact_Name_Display Contact_Email: example@example.com Contact_Phone: 1234567890 Project_Cost_Billing_Date: Project_Cost_Billing_Date Acknowledgement: Yes
MiCores Application for Robin Wylie (2017-2018): ID: 22 Timestamp: 2018-07-23 10:46:01 Project_ID: sbqove PI_Uniqname: wylie PI_Name_First: Robin PI_Name_Last: Wylie PI_Email: wylie@umich.edu PI_Phone: 734-615-9575 PI_Affiliation: Epidemiology Department - Faculty and Staff School of Public Health - Faculty and Staff PI_Title: Web Designer/Administrative Intermediate PI_PostalAddress: Epidemiology 6638 SPH I Ann Arbor MI 48109-2029 Investigator_Membership: Yes Project_Grant_Cycle: 2017-2018 Project_Cost: 999 Project_Description: Ipsum lorem. Project_Cores: Epigenomics, OBIC Project_Cores_OBIC: Ipsum lorem. Project_Assay: Ipsum lorem. Project_Cost_Billing_Date: Project_Cost_Billing_Date Acknowledgement: Yes
MiCores Application for Rita Loch-Caruso (2017-2018): ID: 21 Timestamp: 2018-05-07 17:59:08 Project_ID: wqu0df PI_Uniqname: rlc PI_Name_First: Rita PI_Name_Middle: PI_Name_Middle PI_Name_Last: Loch-Caruso PI_Email: rlc@umich.edu PI_Phone: 734-936-1256 PI_Affiliation: Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff LSA UG: Environment - Faculty and Staff College of Lit, Science & Arts - Faculty and Staff PI_Title: Professor of Toxicology, Department of Environmental Health Sciences, School of Public Health and Professor of Program in the Environment, College of Literature, Science, and the Arts and School of Environment and Sustainability PI_PostalAddress: Environmental Hlth Sci M6108 SPH2, 1415 Washington Hts. Ann Arbor MI 48109-2029 Investigator_Membership: No Project_Grant_Cycle: 2017-2018 Project_Cost: 1400 Project_Description: Project_Description Project_Cores: Bioinformatics, Epigenomics, Metabolomics, EAC, OBIC, IHSC Project_Cores_EAC: Project_Cores_EAC Project_Cores_OBIC: Project_Cores_OBIC Project_Cores_IHSC: Project_Cores_IHSC Project_Assay: Project_Assay Contact_Name_Display: Robin Wylie Contact_Email: wylie@umich.edu Contact_Phone: 734-615-9575 Project_Cost_Billing_Date: Project_Cost_Billing_Date Acknowledgement: Yes
MiCores Application for Rita Loch-Caruso (2017-2018): ID: 20 Timestamp: 2018-05-03 17:14:32 Project_ID: erlys6 PI_Uniqname: rlc PI_Name_First: Rita PI_Name_Middle: PI_Name_Middle PI_Name_Last: Loch-Caruso PI_Email: rlc@umich.edu PI_Phone: 734-936-1256 PI_Affiliation: Environmental Health Sciences - Faculty and Staff School of Public Health - Faculty and Staff LSA UG: Environment - Faculty and Staff College of Lit, Science & Arts - Faculty and Staff PI_Title: Professor of Toxicology, Department of Environmental Health Sciences, School of Public Health and Professor of Program in the Environment, College of Literature, Science, and the Arts and School of Environment and Sustainability PI_PostalAddress: Environmental Hlth Sci M6108 SPH2, 1415 Washington Hts. Ann Arbor MI 48109-2029 Investigator_Membership: No Project_Grant_Cycle: 2017-2018 Project_Cost: 1999 Project_Description: Project_Description Project_Cores: Bioinformatics, Epigenomics, Metabolomics Project_Assay: Project_Assay Contact_Name_Display: Robin Wylie Contact_Email: wylie@umich.edu Contact_Phone: 734-615-9575 Project_Cost_Billing_Date: Project_Cost_Billing_Date Acknowledgement: Yes

Click here to view these applications as a spreadsheeet.